Members
Lin-Tai Da
Tenured Associate Professor (Ph.D. Advisor)
Tel：
Fax：
Fax： darlt@sjtu.edu.cn
Homepage： https://compchembio.sjtu.edu.cn/
Education
2005-2010 Ph.D. in Physical Chemistry with Prof. Yun-Dong Wu, Peking University.
2001-2005 B.Sc in Chemistry, Inner Mongolia University.
Research Experience
2017.1-now Shanghai Jiaotong University
2014.05-2015.11 Postdoctoral with Prof. Huan-Xiang Zhou in Florida State University.
2013.09-2014.05 Postdoctoral with Prof. Xuhui Huang in Chemistry Department, Hong Kong University of Science and Technology.
2013.03-2013.09 Visiting scholar with Prof. Dong Wang in University of California, San Diego.
2010-2013.02 Postdoctoral with Prof. Xuhui Huang in Chemistry Department, Hong Kong University of Science and Technology.
Honors & Awards
2017 入选浦江人才
Siyuan Li
Ph.D. Student
Tel：
Fax：
Email： LiSY_Edgardo@sjtu.edu.cn
Homepage：
Education
Ph.D. Candidate in Biology 2022–Present
Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
Advisor: Prof. Lin-Tai Da
B.S. in Biotechnology 2018–2022
School of Life Sciences andTechnology, Tongji University
Research Experience
Previous Research:
Analysis of transcription factors binding-site searching mechanism and specific binding modes
Current Research Focus:
Prediction and De novo design of specific DNA-binding protein
Hanchen Zhu
Ph.D. Student
Born in 2000, Tanggu District, Tianjin, China
Tel：
Fax：
Email： tjtgzhc20@sjtu.edu.cn
Homepage：
Education
Ph.D. Candidate in Biology 2025–Present Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
Advisor: Prof. Lin-Tai Da
M.Sc. in Microbiology and Biochemical Pharmacy 2022–2025
School of Pharmacy, Nankai University
Advisor: Prof. Rimo-Xi
B.Sc. in Biopharmaceutical 2018–2022
School of Life Science and Technology, China Pharmaceutical University
Research Experience
- Construction of E. coli Recombinant Protein Expression Systems
Developed and optimized expression platforms for bacterial protein production. - Design and Investigation of Novel T Cell–Engaging Antibody Formats
Engineered and characterized next-generation bispecific molecules for immunotherapy.
Current Research Interests
- Machine learning–driven antibody discovery and optimization
- Molecular dynamics–based analysis and design of therapeutic antibodies
Additional Information
- Loyal supporter of Tianjin TEDA FC and Manchester United FC
Ruicheng Qi
Ph.D. Student
Tel：
Fax：
Email： qiruicheng@sjtu.edu.cn
Homepage：
Education
Ph.D. Candidate in Biology 2025–Present
Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
Advisor: Prof. Lin-Tai Da
M.S. Student in Computational Biology 2021–2025
Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences
Advisor: Prof. Guang-zhong Wang
B.S. in Bioengineering 2017–2021
Qian Weichang College, Shanghai University
Research Experience
Previous Research:
Radiomics
Applications of Single-Cell Omics
Current Research Focus:
Deep learning-based analysis of carbohydrate–protein interactions
Wanxiang Yi
M.S. Student
Tel：
Fax：
Email： yiwanxiang@sjtu.edu.cn
Homepage：https://star-explosion.github.io/
Education
M.S. Candidate in Biology 2025–Present
Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
Advisor: Prof. Lin-Tai Da
B.S. in Pharmacy 2021–2025
China Pharmaceutical University – National Center for Life Sciences and Technology Talent Development
Research Experience
Development and pre-validation of a hydrophobic interaction chromatography method for analyzing complex protein formulations
Development of an organic upconversion nanoprobe activatable for monoamine oxidase B bioimaging in Parkinson’s disease
Research on molecular generation in AI-driven drug discovery