Investigating how proteins (including DNA repair enzymes like glycosylases, transcription factors, and CRISPR systems) search for, recognize, and interact with specific DNA sequences through integrated computational and experimental approaches.
02.
Immune Recognition And Antigen Presentation
Studying MHC-peptide loading dynamics, TCR-pMHC interactions, and viral envelope glycoprotein conformational changes to advance neoantigen discovery, vaccine design, and immunotherapy development.
03.
Enzyme mechanism elucidation and engineering
Characterizing catalytic mechanisms of diverse enzymes (glycosyltransferases, peptide ligases, and synthases) and engineering their substrate specificity for biocatalysis, drug discovery, and synthesis of bioactive compounds.
Discover Our Journey
Unveiling the Story Behind Da Lab’s Mission and Vision
Darlintai Lab is dedicated to exploring the intricate interactions between proteins and DNA through cutting-edge research and innovative technology, aiming to unravel fundamental biological questions.
